Founded in 1959 under the auspices of the multilateral Southeast Asia Treaty Organization, AFRIMS has always relied on close relationships with local, national and international collaborators to execute field-leading science. These partnerships, built on a framework of moral and ethical research, afford AFRIMS researchers unique access to locations of concern for infectious disease, including hotspots for malaria drug resistance and understudied communities at risk for HIV. As a result, AFRIMS's modern network of basic and translational laboratories across Southeast Asia work with civilian, military, non-governmental, academic and industry researchers to produce relevant, field-leading science to overcome infectious disease threats to Soldier health and world health.